منابع مشابه
Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels.
Caffeine has various well-characterized pharmacological effects, but in mammals there are no known plasma membrane receptors or ion channels activated by caffeine. We observed that caffeine activates mouse transient receptor potential A1 (TRPA1) in heterologous expression systems by Ca(2+)(i) imaging and electrophysiological analyses. These responses to caffeine were confirmed in acutely dissoc...
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employees always concern about losing their job , or in other word , losing their income resources. for this purpose, every government requires strong system for covering these concerns. the unemployment insurance (ui) program’s can be used for achieving this goal. in this thesis, we price ui based on the insurance history of employee and the duration of being unemployed. we use the weibull dis...
the effect of traffic density on the accident externality from driving the case study of tehran
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15 صفحه اولHow irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways.
Airway irritants cause a variety of lung pathologies. Two separate studies, the first recently reported in the JCI by Bessac et al. and the second reported by Andrè et al. in the current issue of the JCI (see the related article beginning on page 2574), have identified irritants that activate transient receptor potential cation channel, subfamily A, member 1 (TRPA1) receptors in airway sensory ...
متن کاملWeakly acidic, but strongly irritating: TRPA1 and the activation of nociceptors by cytoplasmic acidification
489 C o m m e n t a r y Our bodies and our surroundings contain an enormous array of chemicals. Although many of these chemicals are useful and even essential for survival, others are potentially harmful. A challenge all animals face is to sense which chemicals are useful and which are harmful. Considered in the context of feeding behavior, this challenge is highly asymmetric. Although animals ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2011
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2010.200717